Return-Path: Received: from edge02.suddenlink.net ([67.231.144.34]) by imta01.suddenlink.net (InterMail vM.7.09.02.04 201-2219-117-106-20090629) with ESMTP id <20110624190121.LHEU2645.imta01.suddenlink.net@edge02.suddenlink.net> for ; Fri, 24 Jun 2011 14:01:21 -0500 Received: from mx0a-0007b301.pphosted.com ([67.231.144.34]) by edge02.suddenlink.net (InterMail vG.3.00.03.00 201-2196-126-20070720) with ESMTP id <20110624190121.LOKG3057.edge02.suddenlink.net@mx0a-0007b301.pphosted.com> for ; Fri, 24 Jun 2011 14:01:21 -0500 Received: from pps.filterd (m0000263 [127.0.0.1]) by mx0a-0007b301.pphosted.com (8.14.4/8.14.4) with SMTP id p5OIvYaf016265 for ; Fri, 24 Jun 2011 12:01:19 -0700 Received: from cheetah.it.wsu.edu (cheetah.it.wsu.edu [134.121.139.14]) by mx0a-0007b301.pphosted.com with ESMTP id x4xq18fkb-1 for ; Fri, 24 Jun 2011 12:01:18 -0700 Received: from AD2092B (ad2092-b.vetmed.wsu.edu [134.121.130.52]) by cheetah.it.wsu.edu (8.13.8/8.13.8) with SMTP id p5OJ1IhW020096; Fri, 24 Jun 2011 12:01:18 -0700 Thread-Topic: MDR1 Genotyping Results for Pilot thread-index: AcwyoQ5lIsfaigXcR+GqDExLuE+snA== From: To: Cc: Subject: MDR1 Genotyping Results for Pilot Date: Fri, 24 Jun 2011 12:00:59 -0700 Message-ID: <29548096A5424397B6A08D95ED655412@vetmed.wsu.edu> MIME-Version: 1.0 Content-Type: multipart/alternative; boundary="----=_NextPart_000_00C3_01CC3266.6206AF40" X-Mailer: Microsoft CDO for Windows 2000 Content-Class: urn:content-classes:message Importance: normal Priority: normal X-MimeOLE: Produced By Microsoft MimeOLE V6.1.7600.16807 X-Virus-Scanned: clamav-milter 0.97 at cheetah X-Virus-Status: Clean X-Proofpoint-Virus-Version: vendor=fsecure engine=2.50.10432:5.4.6813,1.0.148,0.0.0000 definitions=2011-06-24_07:2011-06-24,2011-06-24,1970-01-01 signatures=0 X-Proofpoint-Spam-Details: rule=notspam policy=default score=0 spamscore=0 ipscore=0 suspectscore=3 phishscore=0 bulkscore=0 adultscore=0 classifier=spam adjust=0 reason=mlx scancount=1 engine=6.0.2-1012030000 definitions=main-1106240153 X-Cloudmark-Analysis: v=1.1 cv=235U/McmtJgwQyHC5evNkME4YhrZLbp95Hh0w/MB98o= c=1 sm=0 a=Wd6EzwJ0q2AA:10 a=_3qTEJEFexQA:10 a=fFxy78ITAAAA:8 a=C1YVQqT_hIlz3m5GZ9EA:9 a=g8A-qf-sx6aMpQkRsbUA:7 a=wPNLvfGTeEIA:10 a=tXsnliwV7b4A:10 a=gi8T7ehSvLsA:10 a=Cvh3WU40cnzrc677:21 a=QCGohFGIYKTciBCy:21 a=HpAAvcLHHh0Zw7uRqdWCyQ==:117 This is a multi-part message in MIME format. ------=_NextPart_000_00C3_01CC3266.6206AF40 Content-Type: text/plain; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable

MDR1 GENOTYPING = RESULTS

6/24/2011 12:00:59 PM
MDR1 - 21555

Tracy = Merrill
Robersonville, NC

Submission Type: =	Brush
Dog Name: =	Pilot
Dog Breed:	Australian = Shepherd
Test Result:	Normal/Normal

Expl= anation of test results

Normal/Normal=

Thes= e dogs do not carry the mutation, and will not pass on the mutation to = their offspring.These dogs would not be expected to experience = unexpected adverse drug reactions to normal doses of ivermectin, = loperamide (Imodium®), and some anticancer drugs.

Mutant/Mutant=

The= se dogs carry the mutation and can not pass on a normal gene to their = offspring.These dogs would be expected to experience toxicity after = normal doses of loperamide (Imodium®), some anticancer drugs, and = high doses of ivermectin (greater than 50 micrograms per = kilogram).

Mutant/Normal=

The= se dogs carry the mutation and may pass on the mutant gene to their = offspring.These dogs may experience toxicity after normal doses of = loperamide (Imodium®), some anticancer drugs, and high doses of = ivermectin (greater than 50 micrograms per kilogram).

A current = list of problem drugs for dogs with the MDR1 mutation may be found at = this web address:
http://www.vetmed.wsu.edu/VCPL

Mohamed = Jabbes

Mohamed Jabbes
Veterinary Clinical = Pharmacology Laboratory Manager

* = PCR for this service is performed pursuant to an agreement with Roche = Molecular Systems, Inc.
US Patent Number US 6,790,621 B2. Foreign = patents pending for MDR1 testing.

PO Box = 609, Pullman, WA 99163-0609
509-335-3745 . FAX: 509-335-3745 . = vcpl@vetmed.wsu.edu . www.vetmed.wsu.edu/VCPL

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MDR1 GENOTYPING RESULTS

6/24/2011 12:00:59 PM
MDR1 - 21555

Tracy Merrill
Robersonville, NC

Submission Type:	Brush
Dog Name:	Pilot
Dog Breed:	Australian Shepherd
Test Result:	Normal/Normal

Explanation of test results

Normal/Normal

These dogs do not carry the mutation, and will not pass on the mutation to their offspring.These dogs would not be expected to experience unexpected adverse drug reactions to normal doses of ivermectin, loperamide (Imodium®), and some anticancer drugs.

Mutant/Mutant

These dogs carry the mutation and can not pass on a normal gene to their offspring.These dogs would be expected to experience toxicity after normal doses of loperamide (Imodium®), some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram).

Mutant/Normal

These dogs carry the mutation and may pass on the mutant gene to their offspring.These dogs may experience toxicity after normal doses of loperamide (Imodium®), some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram).

A current list of problem drugs for dogs with the MDR1 mutation may be found at this web address:
http://www.vetmed.wsu.edu/VCPL

Mohamed Jabbes

Mohamed Jabbes
Veterinary Clinical Pharmacology Laboratory Manager

* PCR for this service is performed pursuant to an agreement with Roche Molecular Systems, Inc.
US Patent Number US 6,790,621 B2. Foreign patents pending for MDR1 testing.

PO Box 609, Pullman, WA 99163-0609
509-335-3745 . FAX: 509-335-3745 . vcpl@vetmed.wsu.edu . www.vetmed.wsu.edu/VCPL

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